{"id":13077,"date":"2017-01-22T00:07:20","date_gmt":"2017-01-22T03:07:20","guid":{"rendered":"https:\/\/www.tiabeth.com.br\/?p=13077"},"modified":"2017-01-22T00:07:20","modified_gmt":"2017-01-22T03:07:20","slug":"glibenclamida-e-metformina-sao-semelhantes-no-controle-da-glicose-durante-a-diabetes-gestacional","status":"publish","type":"post","link":"https:\/\/www.tiabeth.com.br\/index.php\/2017\/01\/22\/glibenclamida-e-metformina-sao-semelhantes-no-controle-da-glicose-durante-a-diabetes-gestacional\/","title":{"rendered":"Glibenclamida e Metformina s\u00e3o semelhantes no controle da glicose durante a diabetes gestacional"},"content":{"rendered":"<p><a href=\"https:\/\/www.tiabeth.com.br\/wp-content\/uploads\/2017\/01\/Glyburide.jpg\"><img loading=\"lazy\" class=\"aligncenter size-full wp-image-13081\" src=\"https:\/\/www.tiabeth.com.br\/wp-content\/uploads\/2017\/01\/Glyburide.jpg\" alt=\"\" width=\"1000\" height=\"650\" srcset=\"https:\/\/www.tiabeth.com.br\/wp-content\/uploads\/2017\/01\/Glyburide.jpg 1000w, https:\/\/www.tiabeth.com.br\/wp-content\/uploads\/2017\/01\/Glyburide-300x195.jpg 300w, https:\/\/www.tiabeth.com.br\/wp-content\/uploads\/2017\/01\/Glyburide-768x499.jpg 768w, https:\/\/www.tiabeth.com.br\/wp-content\/uploads\/2017\/01\/Glyburide-765x496.jpg 765w\" sizes=\"(max-width: 1000px) 100vw, 1000px\" \/><\/a><\/p>\n<p>Para pacientes com <a href=\"http:\/\/www.clinicaladvisor.com\/diabetes-resource-center\/section\/2036\/\" target=\"_self\">diabetes<\/a> mellitus gestacional\u00a0(DMG), Glibenclamida e Metformina s\u00e3o compar\u00e1veis em termos de controle de glicose e de seguran\u00e7a, de acordo com um estudo publicado na <i>Diabetes Care<\/i>.<\/p>\n<p>Zohar Nachum, MD, do Emek Medical Center em Afula, Israel, e colegas, randomizaram pacientes com o DMG com gesta\u00e7\u00e3o de 13 a 33 semanas cujas glicemias eram mal\u00a0controladas pela dieta para receber glibenclamida ou metformina (53 e 51 pacientes, respectivamente).\u00a0Uma outra droga seria adicionada se o controle glic\u00eamico ideal n\u00e3o fosse alcan\u00e7ado. Se os efeitos adversos ocorressem, a droga seria substitu\u00edda. Seria adicionado a insulina se ambos os tratamentos falhassem.<\/p>\n<p>Os pesquisadores descobriram que Glibenclamida foi incompat\u00edvel em 18 pacientes devido a efeitos adversos e falta de controle glic\u00eamico (6 e 12 pacientes, respectivamente). Metformina falhou em outros 15 pacientes devido a efeitos adversos e falta de controle glic\u00eamico (1 e 14 pacientes, respectivamente).<\/p>\n<p>O grupo de <a href=\"http:\/\/www.clinicaladvisor.com\/diabetes-resource-center\/updated-guideline-for-pharmacologic-treatment-of-t2d\/article\/629636\/\" target=\"_self\">metformina<\/a> teve maior sucesso do tratamento ap\u00f3s terapia de segunda linha em compara\u00e7\u00e3o com o grupo de Glibenclamida (87% vs 50%, respectivamente). Nos grupos de glibenclamida e metformina, 17% e 4% dos pacientes, respectivamente, foram eventualmente tratados com insulina. A necessidade de insulina foi reduzida de 32% para 11% dos pacientes ap\u00f3s a combina\u00e7\u00e3o das drogas. A m\u00e9dia di\u00e1ria de glicose no\u00a0sangue, macrosomia, hipoglicemia neonatal e desequil\u00edbrio eletrol\u00edtico foram compar\u00e1veis entre os grupos.<\/p>\n<p>&#8220;Sua combina\u00e7\u00e3o demonstra uma taxa de efic\u00e1cia elevada com uma significativamente menor necessidade de insulina, com uma poss\u00edvel vantagem para metformina sobre Glibenclamida como terapia de primeira linha&#8221;, observam os autores.<\/p>\n<h2>Refer\u00eancia<\/h2>\n<ol>\n<li>Nachum Z, Zafran N, Salim R, et al Glyburide vs Metformina e sua combina\u00e7\u00e3o para o tratamento de diabetes mellitus gestacional: A estudo randomizado\u00a0controlado. <i>Diabetes Care.<\/i> 2017. <a href=\"http:\/\/care.diabetesjournals.org\/content\/early\/2017\/01\/10\/dc16-2307\" target=\"_blank\">doi:10.2337 \/ dc16-2307<\/a><\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<p><a href=\"http:\/\/www.clinicaladvisor.com\/diabetes-resource-center\/glyburide-and-metformin-have-similar-glucose-control\/article\/631989\/\" target=\"_blank\">http:\/\/www.clinicaladvisor.com\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Para pacientes com diabetes mellitus gestacional\u00a0(DMG), Glibenclamida e Metformina s\u00e3o compar\u00e1veis em termos de controle de glicose e de seguran\u00e7a, de acordo com um estudo publicado na Diabetes Care. Zohar Nachum, MD, do Emek Medical Center em Afula, Israel, e colegas, randomizaram pacientes com o DMG com gesta\u00e7\u00e3o de 13 a 33 semanas cujas glicemias [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":13081,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[19,199,185],"tags":[28,3771,193,3770,1176],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v19.3 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\r\n<title>Glibenclamida e Metformina s\u00e3o semelhantes no controle da glicose durante a diabetes gestacional - TiaBeth.com<\/title>\r\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\r\n<link rel=\"canonical\" href=\"https:\/\/www.tiabeth.com.br\/index.php\/2017\/01\/22\/glibenclamida-e-metformina-sao-semelhantes-no-controle-da-glicose-durante-a-diabetes-gestacional\/\" \/>\r\n<meta property=\"og:locale\" content=\"pt_BR\" \/>\r\n<meta property=\"og:type\" content=\"article\" \/>\r\n<meta property=\"og:title\" content=\"Glibenclamida e Metformina s\u00e3o semelhantes no controle da glicose durante a diabetes gestacional - TiaBeth.com\" \/>\r\n<meta property=\"og:description\" content=\"Para pacientes com diabetes mellitus gestacional\u00a0(DMG), Glibenclamida e Metformina s\u00e3o compar\u00e1veis em termos de controle de glicose e de seguran\u00e7a, de acordo com um estudo publicado na Diabetes Care. Zohar Nachum, MD, do Emek Medical Center em Afula, Israel, e colegas, randomizaram pacientes com o DMG com gesta\u00e7\u00e3o de 13 a 33 semanas cujas glicemias [&hellip;]\" \/>\r\n<meta property=\"og:url\" content=\"https:\/\/www.tiabeth.com.br\/index.php\/2017\/01\/22\/glibenclamida-e-metformina-sao-semelhantes-no-controle-da-glicose-durante-a-diabetes-gestacional\/\" \/>\r\n<meta property=\"og:site_name\" content=\"TiaBeth.com\" \/>\r\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/tiabethcom\" \/>\r\n<meta property=\"article:published_time\" content=\"2017-01-22T03:07:20+00:00\" \/>\r\n<meta property=\"og:image\" content=\"https:\/\/www.tiabeth.com.br\/wp-content\/uploads\/2017\/01\/Glyburide.jpg\" \/>\r\n\t<meta property=\"og:image:width\" content=\"1000\" \/>\r\n\t<meta property=\"og:image:height\" content=\"650\" \/>\r\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\r\n<meta name=\"author\" content=\"nlimonge\" \/>\r\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\r\n<meta name=\"twitter:site\" content=\"@tiabethcom\" \/>\r\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"nlimonge\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. tempo de leitura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutos\" \/>\r\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":[\"Person\",\"Organization\"],\"@id\":\"https:\/\/www.tiabeth.com.br\/#\/schema\/person\/a2f986446141f19f046fea5ed1b20982\",\"name\":\"Raquel Limonge\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"pt-BR\",\"@id\":\"https:\/\/www.tiabeth.com.br\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/www.tiabeth.com.br\/wp-content\/uploads\/2022\/07\/logo_tiabeth.jpg\",\"contentUrl\":\"https:\/\/www.tiabeth.com.br\/wp-content\/uploads\/2022\/07\/logo_tiabeth.jpg\",\"width\":856,\"height\":856,\"caption\":\"Raquel Limonge\"},\"logo\":{\"@id\":\"https:\/\/www.tiabeth.com.br\/#\/schema\/person\/image\/\"},\"sameAs\":[\"https:\/\/www.facebook.com\/tiabethcom\",\"https:\/\/www.instagram.com\/raqueltiabeth\",\"https:\/\/twitter.com\/https:\/\/www.twitter.com\/tiabethcom\"]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.tiabeth.com.br\/#website\",\"url\":\"https:\/\/www.tiabeth.com.br\/\",\"name\":\"TiaBeth.com\",\"description\":\"O maior conte\u00fado sobre diabetes da l\u00edngua portuguesa\",\"publisher\":{\"@id\":\"https:\/\/www.tiabeth.com.br\/#\/schema\/person\/a2f986446141f19f046fea5ed1b20982\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.tiabeth.com.br\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"pt-BR\"},{\"@type\":\"ImageObject\",\"inLanguage\":\"pt-BR\",\"@id\":\"https:\/\/www.tiabeth.com.br\/index.php\/2017\/01\/22\/glibenclamida-e-metformina-sao-semelhantes-no-controle-da-glicose-durante-a-diabetes-gestacional\/#primaryimage\",\"url\":\"https:\/\/www.tiabeth.com.br\/wp-content\/uploads\/2017\/01\/Glyburide.jpg\",\"contentUrl\":\"https:\/\/www.tiabeth.com.br\/wp-content\/uploads\/2017\/01\/Glyburide.jpg\",\"width\":1000,\"height\":650},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.tiabeth.com.br\/index.php\/2017\/01\/22\/glibenclamida-e-metformina-sao-semelhantes-no-controle-da-glicose-durante-a-diabetes-gestacional\/\",\"url\":\"https:\/\/www.tiabeth.com.br\/index.php\/2017\/01\/22\/glibenclamida-e-metformina-sao-semelhantes-no-controle-da-glicose-durante-a-diabetes-gestacional\/\",\"name\":\"Glibenclamida e Metformina s\u00e3o semelhantes no controle da glicose durante a diabetes gestacional - 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