{"id":14561,"date":"2017-05-07T00:40:22","date_gmt":"2017-05-07T03:40:22","guid":{"rendered":"https:\/\/www.tiabeth.com.br\/?p=14561"},"modified":"2017-05-07T00:40:22","modified_gmt":"2017-05-07T03:40:22","slug":"insulina-glargina-u300-e-benefica-no-diabetes-mal-controlado","status":"publish","type":"post","link":"https:\/\/www.tiabeth.com.br\/index.php\/2017\/05\/07\/insulina-glargina-u300-e-benefica-no-diabetes-mal-controlado\/","title":{"rendered":"Insulina Glargina U300 \u00e9 ben\u00e9fica no diabetes mal controlado"},"content":{"rendered":"<p><a href=\"https:\/\/www.tiabeth.com.br\/wp-content\/uploads\/2017\/05\/toujeo2.jpg\"><img loading=\"lazy\" class=\"aligncenter size-full wp-image-14562\" src=\"https:\/\/www.tiabeth.com.br\/wp-content\/uploads\/2017\/05\/toujeo2.jpg\" alt=\"\" width=\"1000\" height=\"650\" srcset=\"https:\/\/www.tiabeth.com.br\/wp-content\/uploads\/2017\/05\/toujeo2.jpg 1000w, https:\/\/www.tiabeth.com.br\/wp-content\/uploads\/2017\/05\/toujeo2-300x195.jpg 300w, https:\/\/www.tiabeth.com.br\/wp-content\/uploads\/2017\/05\/toujeo2-768x499.jpg 768w, https:\/\/www.tiabeth.com.br\/wp-content\/uploads\/2017\/05\/toujeo2-765x496.jpg 765w\" sizes=\"(max-width: 1000px) 100vw, 1000px\" \/><\/a><\/p>\n<p>Pesquisadores do Centro M\u00e9dico Militar Nacional Reed da \u00c1gua conclu\u00edram que os profissionais de sa\u00fade deveriam considerar mudar a prescri\u00e7\u00e3o para pacientes com HbA1c descontrolada em regime basal U100 ou multi-dose de insulina para uma insulina basal de a\u00e7\u00e3o mais prolongada, como a glargina U300. Os resultados da revis\u00e3o retrospectiva foram apresentados na Reuni\u00e3o Anual da AACE 2017.<\/p>\n<p>Insulina Detemir ou insulina Glargina U100 servem como insulina basal comum para pacientes com diabetes mellitus n\u00e3o controlado. As insulinas basais adicionais est\u00e3o agora dispon\u00edveis e podem melhorar o controle glic\u00eamico em doentes considerando os regimes basais padr\u00e3o de insulina. Por exemplo, a insulina glargina U300 \u00e9 uma insulina basal de a\u00e7\u00e3o prolongada tendo uma cobertura basal mais consistente e uma menor variabilidade glic\u00eamica quando compara com\u00a0an\u00e1logos de insulina padr\u00e3o.<\/p>\n<p>&#8220;Nossa institui\u00e7\u00e3o come\u00e7ou a utilizar glargina U300 em uma tentativa de otimizar o controle glic\u00eamico em pacientes que s\u00e3o mal controlados com regimes basais padr\u00e3o&#8221;, explicou o autor principal do estudo Huong Trinh Nguyen, NP. Os dados cl\u00ednicos de um paciente com diabetes tipo 1 e quatro pacientes com diabetes tipo 2 que estavam sendo tratados com glargina basal U100 ou detemir foram analisados. Estes doentes foram ent\u00e3o transferidos para glargina U300 por marca\u00e7\u00e3o com f\u00e1rmaco sem qualquer ajuste inicial da insulina pr\u00e9-prandial ou drogas anti-hiperglic\u00eamicas. Os autores do estudo analisaram a HbA1c, o peso e o IMC dos doentes no in\u00edcio do estudo e 3 meses depois.<\/p>\n<p>No paciente\u00a0com diabetes tipo 1, a altera\u00e7\u00e3o na HbA1c foi de 0,7% enquanto a altera\u00e7\u00e3o HbA1c para os pacientes com diabetes tipo 2 variou entre 1,6 &#8211; 3% 3 meses depois. &#8220;O IMC e o peso dos pacientes permaneceram inalterados aos 3 meses em ambos os grupos&#8221;, explicou a Dra. Trinh.<\/p>\n<p>Um dos pacientes com diabetes tipo 2 tinha uma redu\u00e7\u00e3o nos requerimentos pr\u00e9-prandiais de insulina em 41% e outro paciente n\u00e3o necessitava mais de insulina pr\u00e9-prandial. O paciente com diabetes tipo 1 foi capaz de reduzir a necessidade de insulina prandial em 30%. Al\u00e9m disso, dois dos pacientes que tiveram epis\u00f3dios de hipoglicemia antes de receber insulina glargina U300 tinham resolu\u00e7\u00e3o de hipoglicemia. Globalmente, todos os pacientes do estudo relataram &#8220;bem-estar e complac\u00eancia melhorados&#8221; com o uso de insulina glargina U300.<\/p>\n<p>O estudo\u00a0mostrou uma redu\u00e7\u00e3o do HbA1c e da dose de insulina pr\u00e9-prandial ap\u00f3s a transi\u00e7\u00e3o para a insulina glargina U300. &#8220;Esses resultados do mundo real mostram que a glargina U300 melhora o controle glic\u00eamico com uma poss\u00edvel redu\u00e7\u00e3o nos eventos hipoglic\u00eamicos&#8221;, concluiu o Dr. Trinh.<\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"http:\/\/www.empr.com\/aace-2017\/insulin-glargine-detemir-diabetes-glycemic-control-hypoglycemia\/article\/653404\/\" target=\"_blank\" rel=\"noopener noreferrer\">http:\/\/www.empr.com\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Pesquisadores do Centro M\u00e9dico Militar Nacional Reed da \u00c1gua conclu\u00edram que os profissionais de sa\u00fade deveriam considerar mudar a prescri\u00e7\u00e3o para pacientes com HbA1c descontrolada em regime basal U100 ou multi-dose de insulina para uma insulina basal de a\u00e7\u00e3o mais prolongada, como a glargina U300. Os resultados da revis\u00e3o retrospectiva foram apresentados na Reuni\u00e3o Anual [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":14562,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[19,199],"tags":[87,28,45,964,42,2173,4019],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v19.3 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\r\n<title>Insulina Glargina U300 \u00e9 ben\u00e9fica no diabetes mal controlado - TiaBeth.com<\/title>\r\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\r\n<link rel=\"canonical\" href=\"https:\/\/www.tiabeth.com.br\/index.php\/2017\/05\/07\/insulina-glargina-u300-e-benefica-no-diabetes-mal-controlado\/\" \/>\r\n<meta property=\"og:locale\" content=\"pt_BR\" \/>\r\n<meta property=\"og:type\" content=\"article\" \/>\r\n<meta property=\"og:title\" content=\"Insulina Glargina U300 \u00e9 ben\u00e9fica no diabetes mal controlado - TiaBeth.com\" \/>\r\n<meta property=\"og:description\" content=\"Pesquisadores do Centro M\u00e9dico Militar Nacional Reed da \u00c1gua conclu\u00edram que os profissionais de sa\u00fade deveriam considerar mudar a prescri\u00e7\u00e3o para pacientes com HbA1c descontrolada em regime basal U100 ou multi-dose de insulina para uma insulina basal de a\u00e7\u00e3o mais prolongada, como a glargina U300. 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