{"id":22261,"date":"2019-01-16T22:23:23","date_gmt":"2019-01-17T01:23:23","guid":{"rendered":"https:\/\/www.tiabeth.com.br\/?p=22261"},"modified":"2019-01-16T22:24:02","modified_gmt":"2019-01-17T01:24:02","slug":"analogos-de-insulina-versus-insulina-humana-regular-para-diabetes-tipo-2","status":"publish","type":"post","link":"https:\/\/www.tiabeth.com.br\/index.php\/2019\/01\/16\/analogos-de-insulina-versus-insulina-humana-regular-para-diabetes-tipo-2\/","title":{"rendered":"An\u00e1logos de insulina versus insulina humana regular para diabetes tipo 2"},"content":{"rendered":"\n
\"\"<\/figure>\n\n\n\n

N\u00e3o h\u00e1 benef\u00edcios claros ou danos para a escolha de an\u00e1logos de insulina de a\u00e7\u00e3o curta sobre a insulina humana regular para indiv\u00edduos adultos n\u00e3o gr\u00e1vidas com\u00a0diabetes tipo 2\u00a0, de acordo com uma revis\u00e3o de literatura publicada na\u00a0Cochrane Database of Systematic Reviews<\/em>.<\/p>\n\n\n\n

Esta revis\u00e3o sistem\u00e1tica comparou os efeitos dos an\u00e1logos de insulina de a\u00e7\u00e3o curta (insulina asparte, insulina glulisina e insulina lispro) com os da insulina humana regular em indiv\u00edduos adultos n\u00e3o gr\u00e1vidas com diabetes tipo 2.\u00a0Os dados analisados \u200b\u200bde ensaios cl\u00ednicos randomizados e controlados publicados em todos os idiomas foram encontrados por meio de buscas no Cochrane Central Register de Estudos Controlados, ClinicalTrials.gov, Embase, MEDLINE e na Plataforma Internacional de Registros de Ensaios Cl\u00ednicos da Organiza\u00e7\u00e3o Mundial da Sa\u00fade at\u00e9 31 de outubro de 2018. O autor da revis\u00e3o extraiu os dados e avaliou o risco de vi\u00e9s de forma independente.<\/p>\n\n\n\n

Nos 10 estudos eleg\u00edveis para inclus\u00e3o, 1388 participantes receberam an\u00e1logos de insulina de a\u00e7\u00e3o curta e 1363 receberam insulina humana regular (N = 2751).\u00a0As interven\u00e7\u00f5es duraram entre 24 e 104 semanas (dura\u00e7\u00e3o m\u00e9dia de 41 semanas).\u00a0Os estudos mostraram uma baixa incid\u00eancia de\u00a0eventos\u00a0hipoglic\u00eamicos graves<\/a>\u00a0e sem diferen\u00e7as claras entre os bra\u00e7os de interven\u00e7\u00e3o.\u00a0A varia\u00e7\u00e3o da diferen\u00e7a global da hemoglobina glicosilada A1c foi de -0,03% (95% CI, -0,16 a 0,09;\u00a0P<\/em>\u00a0= 0,60 em 9 estudos com 2608 participantes), mas com evid\u00eancias de baixa certeza e 95% de previs\u00e3o variando de -0,31% a 0,25%.\u00a0O n\u00famero de epis\u00f3dios hipoglic\u00eamicos n\u00e3o graves no geral foi de 0,08 eventos \/ participante \/ m\u00eas (IC 95%, 0,00-0,16;\u00a0P<\/em>\u00a0= 0,05 em 7 estudos com 2667 participantes), mas com evid\u00eancias de certeza muito baixa e 95% de previs\u00e3o variando de -0,03 a 0,19.<\/p>\n\n\n\n

Seis dos estudos (n = 2509) utilizaram m\u00e9todos diferentes para avaliar a hipoglicemia grave, de modo que os resultados n\u00e3o puderam ser resumidos com metan\u00e1lise.\u00a0Nenhum estudo incluiu a mortalidade por todas as causas como desfecho prim\u00e1rio ou investigou os efeitos a longo prazo, e os resultados referentes a epis\u00f3dios hipoglic\u00eamicos noturnos foram question\u00e1veis.\u00a0Nenhum dos estudos foi duplo-cego, tornando o risco de detec\u00e7\u00e3o e vi\u00e9s de desempenho muito alto, e v\u00e1rios mostraram inconsist\u00eancias na forma como os m\u00e9todos e os resultados foram relatados.<\/p>\n\n\n\n

Os pesquisadores conclu\u00edram que, embora nenhuma diferen\u00e7a clara possa ser vista entre os dois bra\u00e7os de tratamento em geral, a certeza da evid\u00eancia era ruim, com evid\u00eancias esparsas sobre desfechos relevantes para o paciente, como complica\u00e7\u00f5es do diabetes e mortalidade por todas as causas. Eles sugeriram que pacientes e m\u00e9dicos deveriam “olhar para as vantagens e desvantagens de diferentes regimes de medica\u00e7\u00e3o, e escolher um tratamento com boa rela\u00e7\u00e3o custo-benef\u00edcio, considerando as necessidades individuais do paciente”.<\/p>\n\n\n\n

Refer\u00eancia<\/strong><\/p>\n\n\n\n

Fullerton B, Siebenhofer A, Jeitler K, et al.\u00a0An\u00e1logos de insulina de a\u00e7\u00e3o curta versus insulina humana regular para adultos, n\u00e3o-gr\u00e1vidas com diabetes mellitus tipo 2<\/a>\u00a0.\u00a0Base de Dados Cochrane Syst Rev.<\/em>\u00a02018; 12: CD013228.<\/p>\n\n\n\n

 <\/p>\n\n\n\n

https:\/\/www.endocrinologyadvisor.com\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

N\u00e3o h\u00e1 benef\u00edcios claros ou danos para a escolha de an\u00e1logos de insulina de a\u00e7\u00e3o curta sobre a insulina humana regular para indiv\u00edduos adultos n\u00e3o gr\u00e1vidas com\u00a0diabetes tipo 2\u00a0, de acordo com uma revis\u00e3o de literatura publicada na\u00a0Cochrane Database of Systematic Reviews. Esta revis\u00e3o sistem\u00e1tica comparou os efeitos dos an\u00e1logos de insulina de a\u00e7\u00e3o curta […]<\/p>\n","protected":false},"author":1,"featured_media":22262,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[19,199],"tags":[],"yoast_head":"\r\nAn\u00e1logos de insulina versus insulina humana regular para diabetes tipo 2 - TiaBeth.com<\/title>\r\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\r\n<link rel=\"canonical\" href=\"https:\/\/www.tiabeth.com.br\/index.php\/2019\/01\/16\/analogos-de-insulina-versus-insulina-humana-regular-para-diabetes-tipo-2\/\" \/>\r\n<meta property=\"og:locale\" content=\"pt_BR\" \/>\r\n<meta property=\"og:type\" content=\"article\" \/>\r\n<meta property=\"og:title\" content=\"An\u00e1logos de insulina versus insulina humana regular para diabetes tipo 2 - TiaBeth.com\" \/>\r\n<meta property=\"og:description\" content=\"N\u00e3o h\u00e1 benef\u00edcios claros ou danos para a escolha de an\u00e1logos de insulina de a\u00e7\u00e3o curta sobre a insulina humana regular para indiv\u00edduos adultos n\u00e3o gr\u00e1vidas com\u00a0diabetes tipo 2\u00a0, de acordo com uma revis\u00e3o de literatura publicada na\u00a0Cochrane Database of Systematic Reviews. 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