{"id":28715,"date":"2022-08-02T17:23:13","date_gmt":"2022-08-02T20:23:13","guid":{"rendered":"https:\/\/www.tiabeth.com.br\/?p=28715"},"modified":"2022-08-02T17:23:13","modified_gmt":"2022-08-02T20:23:13","slug":"a-tecnologia-cour-nanoparticle-interrompe-a-progressao-do-diabetes-tipo-1","status":"publish","type":"post","link":"https:\/\/www.tiabeth.com.br\/index.php\/2022\/08\/02\/a-tecnologia-cour-nanoparticle-interrompe-a-progressao-do-diabetes-tipo-1\/","title":{"rendered":"A tecnologia COUR NanoParticle interrompe a progress\u00e3o do diabetes tipo 1"},"content":{"rendered":"

\"\"A COUR Pharmaceuticals publicou detalhes de um estudo com o Miller Lab da Northwestern University, analisando o\u00a0<\/span>diabetes<\/span><\/a>\u00a0tipo 1 .<\/span><\/strong><\/p>\n

A COUR desenvolve novas nanopart\u00edculas imunomodificadoras (COUR Nanopart\u00edculas ou CNPs) projetadas para reprogramar o sistema imunol\u00f3gico no tratamento de doen\u00e7as autoimunes.<\/span><\/p>\n

Os dados demonstraram toler\u00e2ncia dur\u00e1vel usando sua nova tecnologia de plataforma no modelo diab\u00e9tico n\u00e3o obeso (NOD) de diabetes tipo 1 (T1D), o modelo padr\u00e3o ouro para autoimunidade.\u00a0<\/span><\/p>\n

As descobertas do programa T1D do COUR fornecem prova de princ\u00edpio para uma poss\u00edvel mudan\u00e7a de paradigma no tratamento do T1D para afastar os pacientes do gerenciamento orientado pelo paciente ao longo da vida com ajustes onerosos no estilo de vida e inje\u00e7\u00f5es di\u00e1rias de insulina, interrompendo a progress\u00e3o da doen\u00e7a.\u00a0A empresa disse que o impacto de tal tratamento pode atrasar a necessidade de insulina.\u00a0<\/span><\/p>\n

O manuscrito da pesquisa, \u201cTolerogenic Immune-Modifying Nanoparticles Encapsulating Multiple Recombinant Pancreatic \u03b2 Cell Proteins Prevent Onset and Progression of Type 1 Diabetes in Nonnobese Diabetic Mice\u201d, foi selecionado pelo Journal of Immunology, revisado por pares, como uma das principais leituras de agosto 1 de 2022 e est\u00e1 dispon\u00edvel online em\u00a0<\/span>https:\/\/www.jimmunol.org\/content\/early\/2022\/06\/19\/jimmunol.2200208<\/span><\/a>\u00a0.<\/span><\/p>\n

\u201cResultados emocionantes\u201d<\/span><\/h2>\n

\u201cEsta \u00e9 a primeira vez que uma terapia mant\u00e9m n\u00edveis glic\u00eamicos normais no modelo NOD, um dos modelos mais desafiadores para DM1 e autoimunidade\u201d, disse Stephen Miller, professor de microbiologia-imunologia.\u00a0<\/span><\/p>\n

\u201cNo modelo NOD, o tratamento com a plataforma COUR NanoParticle encapsulando ant\u00edgenos relevantes para doen\u00e7as de camundongos impediu a destrui\u00e7\u00e3o de c\u00e9lulas beta no p\u00e2ncreas, interrompendo a progress\u00e3o da doen\u00e7a.\u00a0O mecanismo de a\u00e7\u00e3o do CNP \u00e9 a indu\u00e7\u00e3o de c\u00e9lulas T reguladoras que inibem a infiltra\u00e7\u00e3o de c\u00e9lulas T autorreativas inflamat\u00f3rias no p\u00e2ncreas, onde de outra forma destruiriam as c\u00e9lulas beta produtoras de insulina.\u00a0O encapsulamento de v\u00e1rios ep\u00edtopos de doen\u00e7as dentro dos CNPs \u00e9 necess\u00e1rio para fornecer cobertura suficiente para interromper a progress\u00e3o da doen\u00e7a complexa, que \u00e9 impulsionada por v\u00e1rios ant\u00edgenos\u201d.<\/span><\/p>\n

\u201cOs resultados deste estudo pr\u00e9-cl\u00ednico s\u00e3o muito empolgantes e a equipe do COUR est\u00e1 apaixonada por trazer a plataforma de nanopart\u00edculas COUR encapsulando ant\u00edgenos relevantes para doen\u00e7as humanas (CNP-103) para a cl\u00ednica para fornecer uma terapia potencial de mudan\u00e7a de vida para pacientes que sofrem de tipo 1 diabetes.\u00a0No ritmo acelerado da inova\u00e7\u00e3o, esta \u00e9 a primeira vez na \u00faltima d\u00e9cada a demonstrar um marco profundo no campo da imunologia\u201d, disse John J. Puisis, fundador e CEO da COUR Pharmaceuticals.<\/span><\/p>\n

CNP-103<\/span><\/h2>\n

O CNP-103 \u00e9 um terap\u00eautico de primeira classe projetado para reprogramar o sistema imunol\u00f3gico para abordar a causa imunol\u00f3gica da doen\u00e7a no diabetes tipo 1.\u00a0O CNP-103 \u00e9 uma abordagem promissora que utiliza nanopart\u00edculas propriet\u00e1rias da COUR que encapsulam v\u00e1rias prote\u00ednas diabetog\u00eanicas humanas para induzir toler\u00e2ncia espec\u00edfica de Ag, devolvendo o equil\u00edbrio ao sistema imunol\u00f3gico por meio de reprograma\u00e7\u00e3o imune espec\u00edfica de ant\u00edgeno para interromper a destrui\u00e7\u00e3o imunomediada de c\u00e9lulas das ilhotas pancre\u00e1ticas.<\/span><\/p>\n

 <\/p>\n

https:\/\/www.labiotech.eu\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

A COUR Pharmaceuticals publicou detalhes de um estudo com o Miller Lab da Northwestern University, analisando o\u00a0diabetes\u00a0tipo 1 . A COUR desenvolve novas nanopart\u00edculas imunomodificadoras (COUR Nanopart\u00edculas ou CNPs) projetadas para reprogramar o sistema imunol\u00f3gico no tratamento de doen\u00e7as autoimunes. Os dados demonstraram toler\u00e2ncia dur\u00e1vel usando sua nova tecnologia de plataforma no modelo diab\u00e9tico n\u00e3o […]<\/p>\n","protected":false},"author":1,"featured_media":28716,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[19,199,186],"tags":[5815,28,5816,39,83,40],"yoast_head":"\r\nA tecnologia COUR NanoParticle interrompe a progress\u00e3o do diabetes tipo 1 - TiaBeth.com<\/title>\r\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\r\n<link rel=\"canonical\" href=\"https:\/\/www.tiabeth.com.br\/index.php\/2022\/08\/02\/a-tecnologia-cour-nanoparticle-interrompe-a-progressao-do-diabetes-tipo-1\/\" \/>\r\n<meta property=\"og:locale\" content=\"pt_BR\" \/>\r\n<meta property=\"og:type\" content=\"article\" \/>\r\n<meta property=\"og:title\" content=\"A tecnologia COUR NanoParticle interrompe a progress\u00e3o do diabetes tipo 1 - TiaBeth.com\" \/>\r\n<meta property=\"og:description\" content=\"A COUR Pharmaceuticals publicou detalhes de um estudo com o Miller Lab da Northwestern University, analisando o\u00a0diabetes\u00a0tipo 1 . 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