{"id":29415,"date":"2022-09-09T16:04:12","date_gmt":"2022-09-09T19:04:12","guid":{"rendered":"https:\/\/www.tiabeth.com.br\/?p=29415"},"modified":"2022-09-09T16:04:12","modified_gmt":"2022-09-09T19:04:12","slug":"celulas-imunes-levam-a-perda-de-celulas-beta-no-diabetes-tipo-2","status":"publish","type":"post","link":"https:\/\/www.tiabeth.com.br\/index.php\/2022\/09\/09\/celulas-imunes-levam-a-perda-de-celulas-beta-no-diabetes-tipo-2\/","title":{"rendered":"C\u00e9lulas imunes levam \u00e0 perda de c\u00e9lulas beta no diabetes tipo 2"},"content":{"rendered":"<p><img loading=\"lazy\" class=\"aligncenter size-full wp-image-29422\" src=\"https:\/\/www.tiabeth.com.br\/wp-content\/uploads\/2022\/09\/vumc.jpg\" alt=\"\" width=\"1000\" height=\"666\" srcset=\"https:\/\/www.tiabeth.com.br\/wp-content\/uploads\/2022\/09\/vumc.jpg 1000w, https:\/\/www.tiabeth.com.br\/wp-content\/uploads\/2022\/09\/vumc-300x200.jpg 300w, https:\/\/www.tiabeth.com.br\/wp-content\/uploads\/2022\/09\/vumc-768x511.jpg 768w, https:\/\/www.tiabeth.com.br\/wp-content\/uploads\/2022\/09\/vumc-150x100.jpg 150w, https:\/\/www.tiabeth.com.br\/wp-content\/uploads\/2022\/09\/vumc-696x464.jpg 696w, https:\/\/www.tiabeth.com.br\/wp-content\/uploads\/2022\/09\/vumc-631x420.jpg 631w\" sizes=\"(max-width: 1000px) 100vw, 1000px\" \/>A obesidade e a supernutri\u00e7\u00e3o aumentam o risco de diabetes tipo 2 por meio de v\u00e1rios mecanismos. Uma delas \u00e9 atrav\u00e9s da perda das c\u00e9lulas beta produtoras de insulina da ilhota pancre\u00e1tica.<\/p>\n<p>Wenbiao Chen, PhD, e colegas mostraram anteriormente que a supernutri\u00e7\u00e3o estressou o ret\u00edculo endoplasm\u00e1tico, a parte da c\u00e9lula beta essencial para a produ\u00e7\u00e3o de insulina. Isso causou a secre\u00e7\u00e3o de sinais inflamat\u00f3rios que atraem macr\u00f3fagos, um tipo de c\u00e9lula imune.<\/p>\n<p>Usando imagens ao vivo em um modelo de peixe-zebra em um novo estudo, eles demonstraram que os macr\u00f3fagos induziram as c\u00e9lulas beta a expressar CXCL8, uma potente prote\u00edna de sinaliza\u00e7\u00e3o. CXCL8, por sua vez, recrutou neutr\u00f3filos, outro tipo de c\u00e9lula imune, que atacou e matou c\u00e9lulas beta associadas a macr\u00f3fagos .<\/p>\n<p>A investiga\u00e7\u00e3o de dois modelos de camundongo confirmou que macr\u00f3fagos e neutr\u00f3filos est\u00e3o aumentados no diabetes tipo 2 e desempenham um papel na patog\u00eanese.<\/p>\n<p>Essas descobertas, publicadas no Cell Reports , sugerem que a morte das c\u00e9lulas beta induzida pela supernutri\u00e7\u00e3o envolve uma comunica\u00e7\u00e3o intrincada entre as c\u00e9lulas beta e as c\u00e9lulas imunes. O direcionamento dessas vias de sinaliza\u00e7\u00e3o pode impedir a perda de c\u00e9lulas beta .<\/p>\n<p>Os coautores do VUMC incluem Bingyuan Yang, PhD, Liu Yang, PhD, Zihan Tang, Sander Haigh, Yulong Gong, Yue Zhang, PhD, Brittney Covington, Karin Bosma, PhD, Xin Tong, PhD, Patrick Page-McCaw, PhD e Maureen Gannon, PhD.<\/p>\n<p>Este estudo foi apoiado pelos Institutos Nacionais de Sa\u00fade DK117147, DK020593, GM119787 e DK007563, e pelo Conselho de Bolsas da China.<\/p>\n<p>por Kelsey Pinckard<\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/news.vumc.org\/2022\/09\/08\/immune-cells-beta-cell-loss-type2diabetes\/\" target=\"_blank\" rel=\"noopener\">https:\/\/news.vumc.org\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A obesidade e a supernutri\u00e7\u00e3o aumentam o risco de diabetes tipo 2 por meio de v\u00e1rios mecanismos. Uma delas \u00e9 atrav\u00e9s da perda das c\u00e9lulas beta produtoras de insulina da ilhota pancre\u00e1tica. Wenbiao Chen, PhD, e colegas mostraram anteriormente que a supernutri\u00e7\u00e3o estressou o ret\u00edculo endoplasm\u00e1tico, a parte da c\u00e9lula beta essencial para a produ\u00e7\u00e3o [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":29422,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[19,199,187],"tags":[997,28,6248,35,6247],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v19.3 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\r\n<title>C\u00e9lulas imunes levam \u00e0 perda de c\u00e9lulas beta no diabetes tipo 2 - TiaBeth.com<\/title>\r\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\r\n<link rel=\"canonical\" href=\"https:\/\/www.tiabeth.com.br\/index.php\/2022\/09\/09\/celulas-imunes-levam-a-perda-de-celulas-beta-no-diabetes-tipo-2\/\" \/>\r\n<meta property=\"og:locale\" content=\"pt_BR\" \/>\r\n<meta property=\"og:type\" content=\"article\" \/>\r\n<meta property=\"og:title\" content=\"C\u00e9lulas imunes levam \u00e0 perda de c\u00e9lulas beta no diabetes tipo 2 - TiaBeth.com\" \/>\r\n<meta property=\"og:description\" content=\"A obesidade e a supernutri\u00e7\u00e3o aumentam o risco de diabetes tipo 2 por meio de v\u00e1rios mecanismos. Uma delas \u00e9 atrav\u00e9s da perda das c\u00e9lulas beta produtoras de insulina da ilhota pancre\u00e1tica. 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