{"id":29447,"date":"2022-09-10T11:49:35","date_gmt":"2022-09-10T14:49:35","guid":{"rendered":"https:\/\/www.tiabeth.com.br\/?p=29447"},"modified":"2022-09-10T11:49:35","modified_gmt":"2022-09-10T14:49:35","slug":"preservacao-da-secrecao-de-peptideo-c-examinada-em-jovens-com-diabetes-tipo-1","status":"publish","type":"post","link":"https:\/\/www.tiabeth.com.br\/index.php\/2022\/09\/10\/preservacao-da-secrecao-de-peptideo-c-examinada-em-jovens-com-diabetes-tipo-1\/","title":{"rendered":"Preserva\u00e7\u00e3o da secre\u00e7\u00e3o de pept\u00eddeo C examinada em jovens com diabetes tipo 1"},"content":{"rendered":"<p><img loading=\"lazy\" class=\"aligncenter size-full wp-image-29448\" src=\"https:\/\/www.tiabeth.com.br\/wp-content\/uploads\/2022\/09\/teste-glicose.jpg\" alt=\"\" width=\"1020\" height=\"666\" srcset=\"https:\/\/www.tiabeth.com.br\/wp-content\/uploads\/2022\/09\/teste-glicose.jpg 1020w, https:\/\/www.tiabeth.com.br\/wp-content\/uploads\/2022\/09\/teste-glicose-300x196.jpg 300w, https:\/\/www.tiabeth.com.br\/wp-content\/uploads\/2022\/09\/teste-glicose-1000x653.jpg 1000w, https:\/\/www.tiabeth.com.br\/wp-content\/uploads\/2022\/09\/teste-glicose-768x501.jpg 768w, https:\/\/www.tiabeth.com.br\/wp-content\/uploads\/2022\/09\/teste-glicose-150x98.jpg 150w, https:\/\/www.tiabeth.com.br\/wp-content\/uploads\/2022\/09\/teste-glicose-696x454.jpg 696w, https:\/\/www.tiabeth.com.br\/wp-content\/uploads\/2022\/09\/teste-glicose-643x420.jpg 643w\" sizes=\"(max-width: 1020px) 100vw, 1020px\" \/>O controle intensivo da glicose por 24 meses n\u00e3o retarda o decl\u00ednio na secre\u00e7\u00e3o residual do pept\u00eddeo C entre os jovens com diabetes tipo 1 de in\u00edcio recente, de acordo com um estudo publicado na edi\u00e7\u00e3o de 8 de setembro do\u00a0<i>New England Journal of Medicine<\/i>.<\/p>\n<p>Charlotte K. Boughton, Ph.D., da Wolfson Diabetes and Endocrine Clinic da Universidade de Cambridge, no Reino Unido, e colegas conduziram um estudo randomizado envolvendo jovens de 10,0 a 16,9 anos dentro de 21 dias do\u00a0<a class=\"textTag\" href=\"https:\/\/medicalxpress.com\/tags\/diagnosis\/\" rel=\"tag\">diagn\u00f3stico de\u00a0<\/a><a class=\"textTag\" href=\"https:\/\/medicalxpress.com\/tags\/diabetes\/\" rel=\"tag\">diabetes<\/a> tipo 1.<\/p>\n<p>Noventa e sete participantes foram aleatoriamente designados para receber 24 meses de terapia h\u00edbrida em circuito fechado ou\u00a0<a class=\"textTag\" href=\"https:\/\/medicalxpress.com\/tags\/therapy\/\" rel=\"tag\">terapia<\/a>\u00a0com insulina padr\u00e3o (51 e 46 participantes, respectivamente).\u00a0A \u00e1rea sob a curva (AUC) para o n\u00edvel plasm\u00e1tico de pept\u00eddeo C (ap\u00f3s um teste de toler\u00e2ncia de refei\u00e7\u00e3o mista) aos 12 meses ap\u00f3s o diagn\u00f3stico foi avaliada como o desfecho prim\u00e1rio.<\/p>\n<p><img loading=\"lazy\" src=\"https:\/\/scx1.b-cdn.net\/csz\/news\/800a\/2022\/preservation-of-c-pept.jpg\" alt=\"Preserva\u00e7\u00e3o da secre\u00e7\u00e3o de pept\u00eddeo C examinada em jovens com DM1\" width=\"800\" height=\"530\" \/><\/p>\n<p>Os pesquisadores n\u00e3o observaram diferen\u00e7a significativa entre os grupos na AUC para o n\u00edvel de pept\u00eddeo C aos 12 meses (m\u00e9dia geom\u00e9trica, 0,35 e 0,46 pmol\/mL com terapia de circuito fechado e controle, respectivamente).\u00a0Aos 24 meses, tamb\u00e9m n\u00e3o houve diferen\u00e7a substancial na AUC para o n\u00edvel de pept\u00eddeo C (m\u00e9dia geom\u00e9trica, 0,18 e 0,24 pmol\/mL, respectivamente).\u00a0A m\u00e9dia aritm\u00e9tica do n\u00edvel de hemoglobina glicada foi 4 e 11 mmol por mol menor no grupo de malha fechada versus o\u00a0<a class=\"textTag\" href=\"https:\/\/medicalxpress.com\/tags\/control+group\/\" rel=\"tag\">grupo controle<\/a>\u00a0em 12 e 24 meses, respectivamente.<\/p>\n<p>&#8220;Um per\u00edodo sustentado de controle h\u00edbrido da glicose em circuito fechado ap\u00f3s o diagn\u00f3stico de diabetes tipo 1 em crian\u00e7as e adolescentes n\u00e3o pareceu prevenir o decl\u00ednio na secre\u00e7\u00e3o residual do pept\u00eddeo C&#8221;, escrevem os autores.<\/p>\n<p><strong>Refer\u00eancia:<\/strong><\/p>\n<ul>\n<li>Charlotte K. Boughton et al, Terapia de circuito fechado e preserva\u00e7\u00e3o da secre\u00e7\u00e3o de pept\u00eddeo C no diabetes tipo 1,\u00a0<i>New England Journal of Medicine<\/i>\u00a0(2022).\u00a0<a href=\"https:\/\/dx.doi.org\/10.1056\/NEJMoa2203496\" target=\"_blank\" rel=\"noopener\" data-doi=\"1\">DOI: 10.1056\/NEJMoa2203496<\/a><\/li>\n<li>Jan Bolinder, CLOuDs Disperse\u2014Top-Notch Glucose Control and Residual C-Peptide Secretion,\u00a0<i>New England Journal of Medicine<\/i>\u00a0(2022).\u00a0<a href=\"https:\/\/dx.doi.org\/10.1056\/NEJMe2209740\" target=\"_blank\" rel=\"noopener\" data-doi=\"1\">DOI: 10.1056\/NEJMe2209740<\/a><\/li>\n<\/ul>\n<div class=\"mt-3\"><strong>Fonte: <\/strong><a href=\"https:\/\/medicalxpress.com\/journals\/new-england-journal-of-medicine\/\"><cite>New England Journal of Medicine<\/cite><\/a><\/div>\n<div><\/div>\n<div><\/div>\n<div><a href=\"https:\/\/medicalxpress.com\/news\/2022-09-c-peptide-secretion-youth-diabetes.html\" target=\"_blank\" rel=\"noopener\">https:\/\/medicalxpress.com\/<\/a><\/div>\n","protected":false},"excerpt":{"rendered":"<p>O controle intensivo da glicose por 24 meses n\u00e3o retarda o decl\u00ednio na secre\u00e7\u00e3o residual do pept\u00eddeo C entre os jovens com diabetes tipo 1 de in\u00edcio recente, de acordo com um estudo publicado na edi\u00e7\u00e3o de 8 de setembro do\u00a0New England Journal of Medicine. Charlotte K. Boughton, Ph.D., da Wolfson Diabetes and Endocrine Clinic [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":29448,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[19,199,186],"tags":[28,6253,6254,39,40],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v19.3 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\r\n<title>Preserva\u00e7\u00e3o da secre\u00e7\u00e3o de pept\u00eddeo C examinada em jovens com diabetes tipo 1 - TiaBeth.com<\/title>\r\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\r\n<link rel=\"canonical\" href=\"https:\/\/www.tiabeth.com.br\/index.php\/2022\/09\/10\/preservacao-da-secrecao-de-peptideo-c-examinada-em-jovens-com-diabetes-tipo-1\/\" \/>\r\n<meta property=\"og:locale\" content=\"pt_BR\" \/>\r\n<meta property=\"og:type\" content=\"article\" \/>\r\n<meta property=\"og:title\" content=\"Preserva\u00e7\u00e3o da secre\u00e7\u00e3o de pept\u00eddeo C examinada em jovens com diabetes tipo 1 - TiaBeth.com\" \/>\r\n<meta property=\"og:description\" content=\"O controle intensivo da glicose por 24 meses n\u00e3o retarda o decl\u00ednio na secre\u00e7\u00e3o residual do pept\u00eddeo C entre os jovens com diabetes tipo 1 de in\u00edcio recente, de acordo com um estudo publicado na edi\u00e7\u00e3o de 8 de setembro do\u00a0New England Journal of Medicine. 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